The Current Dermal Fillers:
Restylane® and Perlane®
What are dermal fillers and what do they do exactly?
• Dermal fillers are those FDA approved substances that are injected into the dermis for the purpose of reducing deep lines and furrows around the mouth, tear troughs, nasal labial folds and lines across the cheek.
• Originally, bovine collagen was used for years, but that had its drawbacks and 2% of the population was allergic to it, so every patient had to be skin tested.
• This was replaced by human collagen which eliminated the need for skin testing but it was difficult to shape and mold to provide a smooth filling.
What is Restylane and Perlane and why do I use it?
• Restylane is an entirely new compound, not made of collagen, but of gel-like hyaluronic acid. This acid is a normal component of the skin and joints and has no allergic effect.
• It had two immediate advantages over collagen, it lasted six months instead of three, and it had twice the filling power over collagen.
• Since its introduction I have not used any collagen but only Restylane.
• Perlane came after and is the same compound with a 20% increase in the size of the molecule. Now this allowed for enhanced filling of deep folds, like those deep nasal labial folds.


